The team is now working on the WordPress Interactivity API. This unblocks the same UX Frontity framework enabled but directly in WordPress Core, fully compatible with the new Site Editor.
A customer using Frontity PRO is planning to migrate to their own development using Frontity Framework and they use the Akismet plugin to prevent spam in the comments.
One of the plugin authors confirmed the compatibility:
Yes, Akismet should be compatible, since the REST API uses the standard WordPress comment functions, and Akismet hooks into the wp_insert_comment action.